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Notes on pyrin inflammasome activation
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An autoinflammatory CDC42 variant M45L demonstrates the mechanism of pyrin inflammasome activation
A study published in Science Immunology in 2026 by Aoki et al. explains the mechanism of pyrin inflammasome activation caused by a specific variant of CDC42, M45L.
An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation
A study published in Science Immunology in August 2026 reveals the mechanism of pyrin inflammasome activation through an N-terminal CDC42 T43I variant.
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