An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation

Source

• Source name: science
• Source kind: paper
• Authors / organization: science
• Venue: science
• Published: 2026-08-17
• Collected: 2026-08-17
• URL: https://www.science.org/doi/10.1126/sciimmunol.aea0515
• PDF: UNKNOWN
• DOI: UNKNOWN
• Registry group: journals_and_publishers
• Evidence role: peer_reviewed_journal
• Language: en
• Country / region: UNKNOWN

Plain-Language Brief

A study published in Science Immunology in August 2026 reveals the mechanism of pyrin inflammasome activation through an N-terminal CDC42 T43I variant.

What the Document Says

• The article discusses two research studies related to pyrin inflammasome activation.
• One study by Shouya Feng et al. focuses on an autoinflammatory CDC42 variant M45L and its role in pyrin inflammasome activation.
• Another study by Mariko Aoki et al. discusses an N-terminal CDC42 T43I variant and its role in pyrin inflammasome activation.

Key Concepts Mentioned

• CDC42
• pyrin inflammasome activation
• research studies

Claims Made by the Document

• The M45L CDC42 variant demonstrates the mechanism of pyrin inflammasome activation (Shouya Feng et al.).
• The N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation (Mariko Aoki et al.).

Evidence Used

• The evidence for the first claim is provided by a research article by Shouya Feng et al.
• The evidence for the second claim is provided by a research article by Mariko Aoki et al.

Methods / Approach

UNKNOWN

Limitations Stated by the Authors

UNKNOWN

Limitations Noted by the Agent

Agent interpretation — not from the source.

UNKNOWN

Open Questions

UNKNOWN

Notes for Future Q&A

May include interpretation. Labeled where it does.

UNKNOWN

Raw Abstract / Excerpt

An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation otherapy Research Article By Shouya Feng Thomas Reygaerts et al. An autoinflammatory CDC42 variant M45L demonstrates the mechanism of pyrin inflammasome activation Research Article By Mariko Aoki Alberto Iannuzzo et al. An N-terminal CDC42 T43I variant reveals the mechanism of pyrin inflammasome activation View Table of Contents Science Robotics Volume 11 Issue 117 August 2026 View Cover ONLINE COVER Special Issue on Humanoid Robots. Many believe that, with their humanlike form factor, humanoids will someday work alongsid