Histological aging signatures for monitoring tissue-specific aging and disease

Source

Source name: nature_medicine
Source kind: paper
Authors / organization: nature_medicine
Venue: nature_medicine
Published: 2026-08-17
Collected: 2026-08-17
URL: https://www.nature.com/articles/s41591-026-04566-5
PDF: UNKNOWN
DOI: UNKNOWN
Registry group: journals_and_publishers
Evidence role: peer_reviewed_journal
Language: en
Country / region: UNKNOWN

Plain-Language Brief

Researchers have analyzed histopathological images of 40 different tissues and combined them with transcriptomic data from blood. They developed aging clocks based on the morphological changes associated with aging in these tissues.

What the Document Says

Whole-slide histopathological images were analyzed from 40 tissue types.
Morphological changes associated with aging were revealed.
These morphological changes, along with transcriptomic data from blood, were used to develop aging clocks for various tissues.
The study was published in Nature Medicine on August 17, 2026.

Key Concepts Mentioned

histopathological images
morphological changes
aging clocks
transcriptomic data

Claims Made by the Document

Morphological changes associated with aging can be revealed through histopathological images.
These morphological changes, when paired with transcriptomic data from blood, can be used to develop aging clocks.

Evidence Used

Whole-slide histopathological images were analyzed from 40 tissue types and morphological changes associated with aging were revealed.

Methods / Approach

UNKNOWN

Limitations Stated by the Authors

UNKNOWN

Limitations Noted by the Agent

Agent interpretation — not from the source.

UNKNOWN

Open Questions

UNKNOWN

Notes for Future Q&A

May include interpretation. Labeled where it does.

UNKNOWN

Raw Abstract / Excerpt

Histological aging signatures for monitoring tissue-specific aging and disease lciparum in Uganda reveals rapid selection of a PX1-associated haplotype linked to reduced susceptibility to commonly used antimalarials. Karamoko Niaré Bersabeh Tafesse Melissa D. Conrad Article Open Access 17 Aug 2026 Histological aging signatures for monitoring tissue-specific aging and disease Whole-slide histopathological images from 40 tissue types reveal morphological changes associated with aging, which, when paired with transcriptomic data from blood, are used to develop aging clocks that reflect tissue